Cellular immune competence in bancroftian filariasis.
Identifieur interne : 00ED96 ( Main/Exploration ); précédent : 00ED95; suivant : 00ED97Cellular immune competence in bancroftian filariasis.
Auteurs : S S Mistry ; D. SubrahmanyamSource :
- The Journal of tropical medicine and hygiene [ 0022-5304 ] ; 1985.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Antigènes d'helminthe, Brugia, Filariose lymphatique, Filarioses, Wuchereria bancrofti.
- pharmacologie : Mitogènes.
- Activation des lymphocytes, Adulte, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Wuchereria bancrofti.
- chemical , pharmacology : Mitogens.
- Adult, Humans, Lymphocyte Activation.
Abstract
Lymphocyte proliferative responses to homologous and heterologous filarial antigens, mitogens and purified protein derivatives (PPD) were analysed in a group of 37 subjects from an area endemic for bancroftian filarial infection. The majority of the subjects without any clinical or parasitological evidence of filariasis (endemic normals) reacted with homologous microfilarial antigens only. Non-treated patients with patent microfilaraemia, did not respond to homologous of heterologous microfilarial antigens. In contrast, diethylcarbamazine (DEC)-treated microfilaraemic patients, reacted with homologous filarial antigens. Patients with elephantiasis reacted to microfilarial and adult worm antigens. Response to PPD was marginally depressed in patent microfilaraemic patients and a rise was observed in elephantiasis cases. Endemic normals exhibited normal response to PPD. Responses to mitogens were depressed throughout the course of the infection.
PubMed: 3915514
Affiliations:
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Le document en format XML
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Subrahmanyam</name></author></analytic><series><title level="j">The Journal of tropical medicine and hygiene</title><idno type="ISSN">0022-5304</idno><imprint><date when="1985" type="published">1985</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Helminth (immunology)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (immunology)</term><term>Humans</term><term>Lymphocyte Activation</term><term>Mitogens (pharmacology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adulte</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Humains</term><term>Mitogènes (pharmacologie)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Mitogènes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Mitogens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adulte</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphocyte proliferative responses to homologous and heterologous filarial antigens, mitogens and purified protein derivatives (PPD) were analysed in a group of 37 subjects from an area endemic for bancroftian filarial infection. The majority of the subjects without any clinical or parasitological evidence of filariasis (endemic normals) reacted with homologous microfilarial antigens only. Non-treated patients with patent microfilaraemia, did not respond to homologous of heterologous microfilarial antigens. In contrast, diethylcarbamazine (DEC)-treated microfilaraemic patients, reacted with homologous filarial antigens. Patients with elephantiasis reacted to microfilarial and adult worm antigens. Response to PPD was marginally depressed in patent microfilaraemic patients and a rise was observed in elephantiasis cases. Endemic normals exhibited normal response to PPD. Responses to mitogens were depressed throughout the course of the infection.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Mistry, S S" sort="Mistry, S S" uniqKey="Mistry S" first="S S" last="Mistry">S S Mistry</name><name sortKey="Subrahmanyam, D" sort="Subrahmanyam, D" uniqKey="Subrahmanyam D" first="D" last="Subrahmanyam">D. Subrahmanyam</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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